Altered lipid raft composition and defective cell death signal transduction in glycosylphosphatidylinositol anchor-deficient PIG-A mutant cells.

Abstract

Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal disorder of haematopoietic stem cells caused by somatic PIGA mutations, resulting in a deficiency in glycosylphosphatidylinositol-anchored proteins (GPI-AP). Because GPI-AP associate with lipid rafts (LR), lack of GPI-AP on PNH cells may result in alterations in LR-dependent signalling. Conversely, PNH… (More)
DOI: 10.1111/j.1365-2141.2008.07203.x

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Cite this paper

@article{Szpurka2008AlteredLR, title={Altered lipid raft composition and defective cell death signal transduction in glycosylphosphatidylinositol anchor-deficient PIG-A mutant cells.}, author={Hadrian Szpurka and Andrew E. Schade and Anna Maria Jankowska and Jaroslaw Maciejewski}, journal={British journal of haematology}, year={2008}, volume={142 3}, pages={413-22} }