Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus.

@article{FloresBorja2007AlteredLR,
  title={Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus.},
  author={Fabian Flores-Borja and Panagiotis S. Kabouridis and Elizabeth C. Jury and David Alan Isenberg and Rizgar A Mageed},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 1},
  pages={291-302}
}
OBJECTIVE B lymphocytes from patients with systemic lupus erythematosus (SLE) exhibit defective intracellular signaling, hyperactivity, and autoantibody production. Recent evidence indicates a reduced expression of Lyn kinase, a negative regulator of B cell signaling, and reduced translocation of Lyn into membrane signaling domains in SLE. The present study was undertaken to investigate the causes of this altered regulation of Lyn by assessing the expression levels of regulatory molecules and… CONTINUE READING