Altered lipid partitioning and glucocorticoid availability in CBG-deficient male mice with diet-induced obesity.

@article{Gulfo2016AlteredLP,
  title={Altered lipid partitioning and glucocorticoid availability in CBG-deficient male mice with diet-induced obesity.},
  author={Jos{\'e} Gulfo and Angelo Ledda and Elisabet Serra and Cristina Cabot and Montserrat Esteve and Mar Grasa},
  journal={Obesity},
  year={2016},
  volume={24 8},
  pages={
          1677-86
        }
}
  • José Gulfo, Angelo Ledda, +3 authors Mar Grasa
  • Published in Obesity 2016
  • Medicine
  • OBJECTIVE To evaluate how deficiency in corticosteroid-binding globulin (CBG), the specific carrier of glucocorticoids, affects glucocorticoid availability and adipose tissue in obesity. METHODS C57BL/6 (WT) and CBG-deficient (KO) male mice were fed during 12 weeks with standard or hyperlipidic diet (HL). Glucocorticoid availability and metabolic parameters were assessed. RESULTS Body weight and food intake were increased in KO compared with WT mice fed a standard diet and were similar when… CONTINUE READING

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