Altered lipid metabolism associated with insulin resistance and obesity is a major contributor to the onset and progression of type 2 diabetes
@inproceedings{Christopher2015AlteredLM,
title={Altered lipid metabolism associated with insulin resistance and obesity is a major contributor to the onset and progression of type 2 diabetes},
author={Michael J. Christopher},
year={2015}
}The Australian population and indeed most of the developed world are facing an obesity epidemic, which is associated with a dramatic increase in the incidence of type 2 diabetes (T2D). Obesity and insulin resistance (IR) are strong predictors of the development of T2D. Dyslipidaemia as assessed by “traditional” measures (raised plasma triglycerides and/or decreased high-density lipoprotein cholesterol) is also a major risk factor for the onset and progression of T2D. However, the measurement of…
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One Citation
Mapping the Associations of the Plasma Lipidome with Insulin Resistance and Response to an Oral Glucose Tolerance Test.
- Medicine, BiologyThe Journal of clinical endocrinology and metabolism
- 2020
The plasma lipidome and changes in lipid levels during an OGTT were associated with indices of insulin resistance, which underlie the involvement of molecular lipid species in the pathogenesis of insulin Resistance and possibly crosstalk between insulin resistance and sex-specific regulation of lipid metabolism.
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