Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers.

@article{Devi1999AlteredLB,
  title={Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers.},
  author={Gayathri R. Devi and Allan T De Souza and James C. Byrd and Randy L. Jirtle and Richard G Macdonald},
  journal={Cancer research},
  year={1999},
  volume={59 17},
  pages={4314-9}
}
The M6P/IGF2R gene, encoding the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor (IGF2R), is frequently inactivated during carcinogenesis. M6P/IGF2R is postulated to be a tumor suppressor gene due to its ability to bind and degrade the mitogen IGF-II, promote activation of the growth inhibitor transforming growth factor beta, and regulate the targeting of lysosomal enzymes. In this study, we determined the effects of four M6P/IGF2R missense mutations associated with loss of… CONTINUE READING
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Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

  • T. Yamada, A. T. De Souza, S. Finkelstein, R. L. Jirtle
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