Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy.

@article{Lanaro2009AlteredLO,
  title={Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy.},
  author={Carolina Lanaro and Carla Fernanda Franco-Penteado and D M Albuqueque and Sara T Olala Saad and Nicola Conran and Fernando Ferreira Costa},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={85 2},
  pages={235-42}
}
Inflammation, cell adhesion to vascular endothelium, and endothelial injury contribute to sickle cell anemia (SCA) vaso-occlusion. Although alterations in inflammatory cytokines and biomarkers have been related, reports have been conflicting, and a conclusive role for these molecules in the disease remains to be established. Furthermore, the effect of hydroxyurea therapy (HU) on the release of inflammatory mediators is not understood. This study aimed to determine plasma levels and leukocyte… CONTINUE READING

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