Altered levels of circulating GABAergic 5α/β-reduced pregnane and androstane steroids in schizophrenic men.

@article{Bikov2011AlteredLO,
  title={Altered levels of circulating GABAergic 5α/β-reduced pregnane and androstane steroids in schizophrenic men.},
  author={Marie Bi{\vc}{\'i}kov{\'a} and Martin Hill and Daniela Ř{\'i}pov{\'a} and Pavel Mohr},
  journal={Hormone molecular biology and clinical investigation},
  year={2011},
  volume={6 2},
  pages={227-30}
}
The role of GABAergic pathways in the pathophysiology of schizophrenia is generally accepted. Therefore, the information concerning alterations of the steroid metabolome associated with the disease and/or its treatment is of interest with regard to the pathophysiology of the disease. Hence, we assessed 18 serum steroids and steroid polar conjugates in a group of drug-naive patients (13 adult men) and after 6-months therapy by atypical antipsychotics and age-matched controls (19 men) using gas… CONTINUE READING

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