Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment.

@article{Vaziri2016AlteredIM,
  title={Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment.},
  author={Nosratola D. Vaziri and Ying-Yong Zhao and Madeleine V. Pahl},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2016},
  volume={31 5},
  pages={
          737-46
        }
}
  • N. Vaziri, Ying-Yong Zhao, M. Pahl
  • Published 2016
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Chronic kidney disease (CKD) results in systemic inflammation and oxidative stress which play a central role in CKD progression and its adverse consequences. Although many of the causes and consequences of oxidative stress and inflammation in CKD have been extensively explored, little attention had been paid to the intestine and its microbial flora as a potential source of these problems. Our recent studies have revealed significant disruption of the colonic, ileal, jejunal and gastric… Expand
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References

SHOWING 1-10 OF 118 REFERENCES
Role of altered intestinal microbiota in systemic inflammation and cardiovascular disease in chronic kidney disease.
TLDR
A review is intended to provide a concise description of the potential role of the CKD-associated changes in the gut microbiome and its potential role the pathogenesis of inflammation and uremic toxicity. Expand
Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation.
TLDR
It is revealed, for the first time, that uremia results in depletion of the key protein constituents of the colonic tight junction, a phenomenon which can account for the impaired intestinal barrier function and contribute to the systemic inflammation in CKD. Expand
Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease
TLDR
Uremia-induced disruption of intestinal TJ and barrier function is, in part, mediated by urea which is generally considered to be a nontoxic retained metabolite, revealing a novel mechanism for a salutary effect of urea-lowering strategies, e.g. low-protein diet and longer and more frequent dialysis regimens in advanced CKD. Expand
Intestinal epithelial barrier function in liver cirrhosis: an extensive review of the literature
TLDR
There are indications for intestinal epithelial barrier dysfunction in patients with chronic liver diseases and especially in Patients with cirrhosis, which can be caused by various factors affecting both the small and large intestine. Expand
Role of Nrf2 Dysfunction in Uremia-Associated Intestinal Inflammation and Epithelial Barrier Disruption
TLDR
The expression profile of inflammatory and tight junction proteins in the colon from CKD rats compared to healthy controls was studied, and the role of Nrf2 (transcription factor nuclear factor erythroid 2-related factor 2) using a potent NRF2 activator was demonstrated. Expand
Chronic Kidney Disease Causes Disruption of Gastric and Small Intestinal Epithelial Tight Junction
TLDR
The present study extends the earlier finding of uremia-induced disruption of colonic epithelial TJ by documenting the involvement of the stomach, jejunum, and ileum as well. Expand
Uremic Plasma Impairs Barrier Function and Depletes the Tight Junction Protein Constituents of Intestinal Epithelium
TLDR
Findings point to the presence of as-yet unidentified product(s) in the uremic plasma capable of depleting epithelial TJ and impairs its barrier function, events which are mediated by agents which are partially removed by hemodialysis. Expand
The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
TLDR
Direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia is demonstrated using models of human inflammatory bowel disease and colorectal carcinoma, and a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic (NOD) mice. Expand
Gut Microbial Translocation in the Pathogenesis of Systemic Inflammation in Patients with End-Stage Renal Disease
  • N. Vaziri
  • Biology, Medicine
  • Digestive Diseases and Sciences
  • 2014
TLDR
There is mounting evidence that advanced CKD impairs intestinal epithelial barrier structure and function, thereby enabling the entry of endotoxin and other bacterial components in the intestinal wall and systemic circulation. Expand
Chronic kidney disease alters intestinal microbial flora.
TLDR
Uremia profoundly alters the composition of the gut microbiome and the biological impact of this phenomenon is unknown and awaits further investigation. Expand
...
1
2
3
4
5
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