Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.

@article{Budde2005AlteredIO,
  title={Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.},
  author={Bastian Budde and Katrin Blumbach and Joni Yl{\"o}stalo and Frank Zaucke and Harald W A Ehlen and Raimund Wagener and Leena M Ala-Kokko and Mats Paulsson and Peter Bruckner and Susanne Gr{\"a}ssel},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 23},
  pages={10465-78}
}
The matrilins are a family of four noncollagenous oligomeric extracellular matrix proteins with a modular structure. Matrilins can act as adapters which bridge different macromolecular networks. We therefore investigated the effect of collagen IX deficiency on matrilin-3 integration into cartilage tissues. Mice harboring a deleted Col9a1 gene lack synthesis of a functional protein and produce cartilage fibrils completely devoid of collagen IX. Newborn collagen IX knockout mice exhibited… CONTINUE READING

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