Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

@article{Scheja1999AlteredIS,
  title={Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.},
  author={Ludger Scheja and Liza Makowski and K. Teoman Uysal and Sarah M. Wiesbrock and Derya R. Shimshek and Daniel S Meyers and Melari Morgan and Rex A. Parker and G{\"o}khan S Hotamisligil},
  journal={Diabetes},
  year={1999},
  volume={48 10},
  pages={1987-94}
}
Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma lipids and adipocyte development but provides significant protection from dietary obesity-induced hyperinsulinemia and insulin resistance. To identify potential mechanisms responsible for this phenotype, we examined lipolysis and insulin secretion in aP2-/- mice. Beta-adrenergic stimulation resulted in a blunted rise of blood glycerol levels in aP2… CONTINUE READING

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