Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+and NO.

@article{Ren1998AlteredIR,
  title={Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+and NO.},
  author={Jun Ren and Mary F. Walsh and Marwan Hamaty and James R. Sowers and Ricardo A. Brown},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={275 3},
  pages={H823-H830}
}
Normally, insulin-like growth factor I (IGF-I) exerts positive effects on cardiac growth and myocardial contractility, but resistance to its action has been reported in diabetes. This study was designed to determine whether IGF-I-induced myocardial contractile action is altered in diabetes as a result of an intrinsic alteration of contractile properties at the cellular level. Contractile responses to IGF-I were examined in left ventricular papillary muscles and ventricular myocytes from normal… CONTINUE READING
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