Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+ and NO.

Abstract

Normally, insulin-like growth factor I (IGF-I) exerts positive effects on cardiac growth and myocardial contractility, but resistance to its action has been reported in diabetes. This study was designed to determine whether IGF-I-induced myocardial contractile action is altered in diabetes as a result of an intrinsic alteration of contractile properties at… (More)

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@article{Ren1998AlteredIR, title={Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+ and NO.}, author={J. Ren and M. F. Walsh and Marwan Hamaty and James R. Sowers and R. A. Brown}, journal={The American journal of physiology}, year={1998}, volume={275 3 Pt 2}, pages={H823-30} }