Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.

@article{Hawn2007AlteredIR,
  title={Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.},
  author={Thomas Richard Hawn and William Richard Berrington and Ian A. Smith and Satoshi Uematsu and Shizuo Akira and Alan Aderem and Kelly D. Smith and Shawn J. Skerrett},
  journal={Journal of immunology},
  year={2007},
  volume={179 10},
  pages={6981-7}
}
Legionella pneumophila (Lp), an important cause of morbidity and mortality from pneumonia, infects alveolar macrophages (AMs) and is recognized by several TLRs as well as Birc1e (NAIP5) and IL-1 converting enzyme-protease activating factor. We examined the role of TLR5 during the murine response to aerosolized Lp infection. At 4 h after infection, Tlr5(-/-) mice had lower numbers of polymorphonuclear neutrophils (PMNs) in their broncho-alveolar lavage fluid in comparison to wild-type (WT) mice… CONTINUE READING