Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.

@article{Penkowa2001AlteredIR,
  title={Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.},
  author={Milena Penkowa and Carmen Espejo and Eva Mar{\'i}a Mart{\'i}nez-C{\'a}ceres and Christian Bj\orn Poulsen and Xavier Montalban and Juan Hidalgo},
  journal={Journal of neuroimmunology},
  year={2001},
  volume={119 2},
  pages={248-60}
}
Metallothionein-I+II (MT-I+II) are antioxidant, neuroprotective proteins, and in this report we have examined their roles during experimental autoimmune encephalomyelitis (EAE) by comparing MT-I+II-knock-out (MTKO) and wild-type mice. We herewith show that EAE susceptibility is higher in MTKO mice relatively to wild-type mice, and that the inflammatory… CONTINUE READING