Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness

@article{Sawada2002AlteredIO,
  title={Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness},
  author={Ken Sawada and Claire Young and Alasdair M Barr and K E Longworth and Satoru Takahashi and Victoria Arango and J. John Mann and Andrew J. Dwork and Peter G Falkai and Anthony G Phillips and William G Honer},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={484-492}
}
Recent imaging and postmortem studies suggest that impaired connectivity is involved in the pathophysiology of schizophrenia and major affective disorders. We investigated the presynaptic proteins complexin (Cx) I and Cx II in postmortem prefrontal cortex in schizophrenia (n = 13; six suicide, seven nonsuicide), major depression (n= 11, all suicide) and controls (n = 11) with an enzyme-linked immunoadsorbent assay (ELISA). Overall analysis indicated a significant difference between groups (F… CONTINUE READING

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