Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp.

@article{AlHassi2014AlteredHG,
  title={Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp.},
  author={Hafid Omar Al-Hassi and Elizabeth R Mann and Borja S{\'a}nchez and Nicholas R. English and Simon T C Peake and Jonathan Landy and Ripple Man and Maria C Urdaci and Ailsa L. Hart and Luis Fern{\'a}ndez-Salazar and Gui Han Lee and Jos{\'e} Antonio Blanco Garrote and E. Plaza Arranz and Abelardo Margolles and Andrew J. Stagg and Stella C. Knight and David Bernardo},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 5},
  pages={
          1132-43
        }
}
SCOPE The human/microbiota cross-talk is partially mediated by bacteria-derived peptides like Serine-Threonine peptide (STp), which is resistant to gut proteolysis, is found in the human healthy colon and induces regulatory properties on gut dendritic cells (DCs); here we characterized human gut DC in ulcerative colitis (UC) patients and studied the effect of STp on their properties. METHODS AND RESULTS Human colonic DC from healthy controls and UC patients were isolated, conditioned for 24 h… CONTINUE READING

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