Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice.

  title={Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice.},
  author={Laura A Volpicelli-Daley and Ellen Duysen and Oksana Lockridge and Allan I. Levey},
  journal={Annals of neurology},
  volume={53 6},
A primary therapeutic strategy for Alzheimer's disease includes acetylcholinesterase (AChE) inhibitors with the goal of enhancing cholinergic transmission. Stimulation of muscarinic acetylcholine receptors (mAChRs) by elevated levels of ACh plays a role in the effects of AChE inhibitors on cognition and behavior. However, AChE inhibitors only demonstrate modest symptomatic improvements. Chronic treatment with these drugs may cause mAChR downregulation and consequently limit the treatment… CONTINUE READING


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