Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model.

@article{Hendriksen2001AlteredHG,
  title={Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model.},
  author={Hendrikus Hendriksen and Nicole A Datson and Wim E. J. M. Ghijsen and E A van Vliet and Fernando H Lopes da Silva and Jan A. Gorter and E. Vreugdenhil},
  journal={The European journal of neuroscience},
  year={2001},
  volume={14 9},
  pages={1475-84}
}
Neuronal loss, gliosis and axonal sprouting in the hippocampal formation are characteristics of the syndrome of mesial temporal sclerosis (MTS). In the post-status epilepticus (SE) rat model of spontaneous seizures these features of the MTS syndrome can be reproduced. To get a global view of the changes in gene expression in the hippocampus we applied serial analysis of gene expression (SAGE) during the early phase of epileptogenesis (latent period), prior to the onset of the first spontaneous… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…