Altered hippocampal gene expression 2 days after general anesthesia in rats.

@article{Culley2006AlteredHG,
  title={Altered hippocampal gene expression 2 days after general anesthesia in rats.},
  author={Deborah J. Culley and Rustam Y. Yukhananov and Zhongcong Xie and Reddy R Gali and Rudolph E. Tanzi and Gregory Crosby},
  journal={European journal of pharmacology},
  year={2006},
  volume={549 1-3},
  pages={
          71-8
        }
}
We profiled changes in gene expression in the hippocampus 2 days after a 4 h general anesthetic with isoflurane and nitrous oxide. Eighteen month old Fisher 344 rats were anesthetized for 4 h with 1.2% isoflurane and 70% nitrous oxide (N=9) whereas control rats breathed 30% oxygen for 4 h (N=9). Rats were sacrificed 48 h later and RNA extracted from the hippocampus for gene expression profiling. Three gene arrays were used per group, with samples prepared by pooling RNA from three rats… CONTINUE READING
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