Altered hepatic foci in rat liver as weight of evidence of carcinogenicity: the Canadian perspective.


The use of AHF in the rat as a predictive lesion for carcinogenesis has been frequently suggested. Regulatory agencies require that the data used to determine carcinogenic potential and for estimating risk cannot be open to different interpretations. The degree of uncertainty in establishing relationships between the different foci phenotypes, their fate… (More)


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