Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification.

@article{Viviano2005AlteredHI,
  title={Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification.},
  author={Beth L. Viviano and Laura Silverstein and Camila Pflederer and Stephenie Paine-Saunders and Kathy E. Mills and Scott Saunders},
  journal={Developmental biology},
  year={2005},
  volume={282 1},
  pages={152-62}
}
Loss of function mutations in the gene encoding the heparan sulfate proteoglycan Glypican-3 (GPC3) causes an X-linked disorder in humans known as Simpson-Golabi-Behmel Syndrome (SGBS). This disorder includes both pre- and postnatal overgrowth, a predisposition to certain childhood cancers, and a complex assortment of congenital defects including skeletal… CONTINUE READING