Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins.

@article{Morrell2001AlteredGR,
  title={Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins.},
  author={Nicholas W Morrell and Xiuwei Yang and Paul D Upton and Karen B Jourdan and N N Morgan and Karen K. K. Sheares and Richard C Trembath},
  journal={Circulation},
  year={2001},
  volume={104 7},
  pages={790-5}
}
BACKGROUND Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a receptor member of the transforming growth factor-beta (TGF-beta) superfamily, underlie many cases of familial and sporadic primary pulmonary hypertension (PPH). We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members. METHODS AND RESULTS For studies of (3)H-thymidine incorporation or cell… CONTINUE READING