Altered glycosylation of proteins produced by malignant cells, and application for the diagnosis and immunotherapy of tumours.

@article{Kobata2005AlteredGO,
  title={Altered glycosylation of proteins produced by malignant cells, and application for the diagnosis and immunotherapy of tumours.},
  author={Akira Kobata and Junko Amano},
  journal={Immunology and cell biology},
  year={2005},
  volume={83 4},
  pages={
          429-39
        }
}
Most secretory and membrane-bound proteins produced by mammalian cells contain covalently linked sugar chains. Alterations of the sugar chain structures of glycoproteins have been found to occur in various tumours. Because the sugar chains of glycoproteins are essential for the maintenance of the ordered social behaviour of differentiated cells in multicellular organisms, alterations to the sugar chains are the molecular basis of abnormal social behaviours in tumour cells, such as invasion into… CONTINUE READING

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