Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements.

@article{Bieback2010AlteredGE,
  title={Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements.},
  author={K Bieback and Viet Anh-Thu Ha and Andrea Hecker and Melanie Grassl and Sven Kinzebach and Hermann Solz and Carsten Sticht and Harald Kl{\"u}ter and Peter Bugert},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 11},
  pages={3467-84}
}
Mesenchymal stromal cells (MSCs) are promising candidates for innovative cell therapeutic applications. For clinical scale manufacturing regulatory agencies recommend to replace fetal bovine serum (FBS) commonly used in MSC expansion media as soon as equivalent alternative supplements are available. We already demonstrated that pooled blood group AB human serum (HS) and thrombin-activated platelet releasate plasma (tPRP) support the expansion of multipotent adipose tissue-derived MSCs (ASCs… CONTINUE READING

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