Altered gene expression in gingival tissues and enhanced bone loss in rats with diabetes with experimental periodontitis.

@article{Soboku2014AlteredGE,
  title={Altered gene expression in gingival tissues and enhanced bone loss in rats with diabetes with experimental periodontitis.},
  author={Kyoko Soboku and Takeshi Kikuchi and Sachiko Fujita and Hiroaki Takeda and Keiko Naruse and Tatsuaki Matsubara and Toshihide Noguchi},
  journal={Journal of periodontology},
  year={2014},
  volume={85 3},
  pages={455-64}
}
BACKGROUND Systemic hyperglycemia is clearly related to severity of periodontitis, meaning that periodontitis can be exacerbated by diabetes mellitus (DM). However, the biologic mechanisms responsible for this relationship remain unclear. Thus, in this study, the global gene expression in gingival tissue with periodontitis is profiled in Zucker diabetic fatty (ZDF) rats compared with Zucker normoglycemic littermates (Lean). METHODS At age 8 weeks, ZDF and Lean rats received ligature placement… CONTINUE READING