Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.

@article{Warren2014AlteredGE,
  title={Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.},
  author={Brandon L. Warren and Omar K. Sial and Lyonna F. Alcantara and Maria A. Greenwood and J. Stephen Brewer and John P Rozofsky and Eric M. Parise and Carlos A. Bola{\~n}os-Guzm{\'a}n},
  journal={Developmental neuroscience},
  year={2014},
  volume={36 3-4},
  pages={
          250-60
        }
}
Stressful early life experiences are implicated in lifelong health. However, little is known about the consequences of emotional stress (ES) or physical stress (PS) on neurobiology. Therefore, the following set of experiments was designed to assess changes in transcription and translation of key proteins within the nucleus accumbens (NAc). Male adolescent (postnatal day 35) or adult (8-week-old) mice were exposed to ES or PS using a witness social defeat paradigm. Then, 24 h after the last… CONTINUE READING
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