Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2.

@article{Zeeland2010AlteredFC,
  title={Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2.},
  author={Ashley A. Scott-Van Zeeland and Brett S. Abrahams and Ana Isabel Alvarez-Retuerto and Lisa I. Sonnenblick and Jeffrey D. Rudie and Dara Ghahremani and Jeanette A. Mumford and Russell A. Poldrack and Mirella Dapretto and Daniel H. Geschwind and Susan Y. Bookheimer},
  journal={Science translational medicine},
  year={2010},
  volume={2 56},
  pages={56ra80}
}
Genetic studies are rapidly identifying variants that shape risk for disorders of human cognition, but the question of how such variants predispose to neuropsychiatric disease remains. Noninvasive human brain imaging allows assessment of the brain in vivo, and the combination of genetics and imaging phenotypes remains one of the only ways to explore functional genotype-phenotype associations in human brain. Common variants in contactin-associated protein-like 2 (CNTNAP2), a neurexin superfamily… CONTINUE READING

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