Altered function of pulmonary surfactant in fatty acid lung injury.

  title={Altered function of pulmonary surfactant in fatty acid lung injury.},
  author={Stephen C. Hall and Robert H. Notter and Roger J Smith and Richard W Hyde},
  journal={Journal of applied physiology},
  volume={69 3},
To determine whether acute fatty acid lung injury impairs pulmonary surfactant function, we studied anesthetized ventilated rabbits given oleic acid (55 mg/kg iv, n = 11) or an equivalent volume of saline (n = 8). Measurements of pulmonary mechanics indicated a decrease in dynamic compliance within 5 min of injury and a decrease in lung volume that was disproportionately large at low pressures, consistent with diminished surfactant activity in vivo. Bronchoalveolar lavage fluid obtained 1 h… CONTINUE READING


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