Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism

@article{Warre2011AlteredFO,
  title={Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism},
  author={Ruth Warre and Sherri L Thiele and Sheena Talwar and Marium Kamal and Joanne E. Nash},
  journal={Neurobiology of Disease},
  year={2011},
  volume={41},
  pages={591-604}
}
OBJECTIVE In Parkinson's disease, chronic striatal dopamine depletion results in over-activity and under-activity of the indirect and direct striatal output pathways respectively. In this study, we investigated changes in the function of glutamatergic cortico-striatal synapses that contribute to abnormalities in striatal efferents. METHODS Whole-cell recordings were performed in striatal slices prepared from adult bacterial artificial chromosome mice, chronically lesioned with 6… CONTINUE READING

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