Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy

@inproceedings{Kraft2019AlteredFG,
  title={Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy},
  author={Theresia Kraft and Judith Montag},
  booktitle={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2019}
}
Hypertrophic cardiomyopathy (HCM) is mainly caused by mutations in sarcomeric proteins. Thirty to forty percent of identified mutations are found in the ventricular myosin heavy chain (β-MyHC). A common mechanism explaining how numerous mutations in several different proteins induce a similar HCM-phenotype is unclear. It was proposed that HCM-mutations cause hypercontractility, which for some mutations is thought to result from mutation-induced unlocking of myosin heads from a so-called super… CONTINUE READING

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Advanced Evolution of Pathogenesis Concepts in Cardiomyopathies

  • Journal of clinical medicine
  • 2019
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