Altered flow-induced arterial remodeling in vimentin-deficient mice.

@article{Schiffers2000AlteredFA,
  title={Altered flow-induced arterial remodeling in vimentin-deficient mice.},
  author={Paul M. H. Schiffers and Daniel Henrion and Chantal M Boulanger and Emma Colucci-Guyon and F Langa-Vuves and Helma van Essen and Gregorio E. Fazzi and Bernard I L{\'e}vy and Jo G R De Mey},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 3},
  pages={
          611-6
        }
}
The endothelial cytoskeleton plays a key role in arterial responses to acute changes in shear stress. We evaluated whether the intermediate filament protein vimentin is involved in the structural responses of arteries to chronic changes in blood flow (BF). In wild-type mice (V+/+) and in vimentin-deficient mice (V-/-), the left common carotid artery (LCA) was ligated near its bifurcation, and 4 weeks later, the structures of the occluded and of the contralateral arteries were evaluated and… CONTINUE READING

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