Altered flecainide disposition in healthy volunteers taking quinine

  title={Altered flecainide disposition in healthy volunteers taking quinine},
  author={Alain Munafo and G. Reymond-Michel and J{\'e}r{\^o}me Biollaz},
  journal={European Journal of Clinical Pharmacology},
The pharmacokinetics of flecainide and its two sequential metabolites, both free and conjugated, its pharmacodynamics, and the influence of simultaneously administered quinine, have been studied in 10 healthy subjects. The study comprised two, 48-h open phases at an interval of 1 week. Flecainide acetate 150 mg was given as a 30-min i.v. infusion and quinine sulphate orally 500 mg×3 over 24 h. Quinine administration did not change the apparent volume of distribution or the renal clearance of… CONTINUE READING