Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.

@article{Wang2008AlteredFG,
  title={Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.},
  author={Jianghua H Wang and Wendong Yu and Yi Cai and Chengxi Ren and Michael Ittmann},
  journal={Neoplasia},
  year={2008},
  volume={10 8},
  pages={847-56}
}
Fibroblast growth factor receptor 4 (FGFR-4) is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous. A common polymorphism of FGFR-4 in which arginine (Arg(388)) replaces glycine (Gly(388)) at amino acid 388 is associated with progression in human prostate cancer. We show that the FGFR-4 Arg(388) polymorphism, which is present in most prostate cancer patients, results in increased receptor stability and sustained receptor activation… CONTINUE READING