Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells.

Abstract

BACKGROUND Platelet-derived growth factor-BB (PDGF-BB) is a profibrotic factor in liver fibrosis through its ability to stimulate hepatic stellate cells (HSC). The liver-derived serine protease factor VII activating protease (FSAP) regulates the activities of PDGF-BB in a cell-specific manner. AIMS Our aim was to determine the influence of FSAP on the… (More)
DOI: 10.1111/j.1478-3231.2008.01897.x

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