Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors

@article{Lengyel2012AlteredEP,
  title={Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors},
  author={Zsuzsanna Lengyel and Csenge Lovig and Siri Kommedal and Rita Keszthelyi and Gy{\"o}rgy Szekeres and Zita Batty{\'a}ni and Val{\'e}r J Csernus and Andr{\'a}s D{\'a}vid Nagy},
  journal={Tumor Biology},
  year={2012},
  volume={34},
  pages={811-819}
}
The majority of our genes may be regulated in a daily rhythm, including the genes for cell cycle control. Epidemiological and genetic evidences suggest that disruption of circadian timing mechanisms makes our cells more vulnerable to cancer formation. The aim of this study was to investigate the relationship between expression patterns of circadian clock genes (period homolog (per)1, per2, clock, and cry1) and tumor development by analyzing human skin biopsies of malignant melanoma and… CONTINUE READING

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