Altered expression of tumor suppressors p16 and Rb in gastric carcinogenesis.

AIM To determine whether expression of the tumor suppressors p16 and Rb is altered in gastric carcinoma. METHODS Mucosal biopsies were endoscopically obtained from patients with superficial gastritis (n = 12), atrophic gastritis (n = 15), atypical hyperplasia (n = 20) and gastric cancer (n = 40). Upon obtainment, all samples were immediately fixed with 10… CONTINUE READING