Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells

  title={Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells},
  author={R. Ummanni and S. Teller and H. Junker and U. Zimmermann and S. Venz and C. Scharf and J. Giebel and R. Walther},
  journal={The FEBS Journal},
  • R. Ummanni, S. Teller, +5 authors R. Walther
  • Published 2008
  • Biology, Medicine
  • The FEBS Journal
  • Tumor protein D52 (TPD52) is a protein found to be overexpressed in prostate and breast cancer due to gene amplification. However, its physiological function remains under investigation. In the present study, we investigated the response of the LNCaP human prostate carcinoma cell line to deregulation of TPD52 expression. Proteomic analysis of prostate biopsies showed TPD52 overexpression at the protein level, whereas its transcriptional upregulation was demonstrated by real‐time PCR… CONTINUE READING
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