Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils.

@article{Sussman1998AlteredEO,
  title={Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils.},
  author={Mark A Sussman and Susanna Baqu{\'e} and C S Uhm and Mathew P. Daniels and Robert L. Price and Dennis Simpson and Louis Terracio and L. Kedes},
  journal={Circulation research},
  year={1998},
  volume={82 1},
  pages={94-105}
}
Tropomodulin is a tropomyosin-binding protein that terminates "pointed-end" actin filament polymerization. To test the hypothesis that regulation of tropomodulin:actin filament stoichiometry is critical for maintenance of actin filament length, tropomodulin levels were altered in cells by infection with recombinant adenoviral expression vectors, which produce either sense or antisense tropomodulin mRNA. Neonatal rat cardiomyocytes were infected, and sarcomeric actin filament organization was… CONTINUE READING

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