Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

@article{Jiang1993AlteredEO,
  title={Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.},
  author={Wei Jiang and Yi Zhang and Scott M. Kahn and Monica C. Hollstein and Regina M. Santella and S. H. Lu and Curtis C. Harris and R. Montesano and I. Bernard Weinstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 19},
  pages={9026-30}
}
We have examined DNA from four human esophageal carcinoma cell lines and 50 primary esophageal carcinomas obtained from China, Italy, and France for amplification of the cyclin D1 gene. We also examined 36 of these 50 carcinomas for expression of the cyclin D1 and retinoblastoma (RB) proteins by immunohistochemistry. We found a 3- to 10-fold amplification of the cyclin D1 gene in 16 of the 50 (32%) tumors and in two of the four cell lines. Cyclin D1 protein was overexpressed in 12 of 13 tumors… CONTINUE READING