Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse.

@article{Israelsson2014AlteredEO,
  title={Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse.},
  author={Charlotte Israelsson and Johanna Flygt and Elaine {\AA}strand and Olivia Kiwanuka and Henrik Bengtsson and Niklas Marklund},
  journal={Restorative neurology and neuroscience},
  year={2014},
  volume={32 5},
  pages={717-31}
}
PURPOSE When central nervous system axons are injured, regeneration is partly inhibited by myelin-associated inhibitors (MAIs). Following traumatic brain injury (TBI) in the rat, pharmacological neutralisation of the MAIs Nogo-A and myelin-associated glycoprotein (MAG) resulted in improved functional outcome. In contrast, genetic or pharmacological neutralization of the MAI receptors Nogo-66 receptor 1 (NgR1) or paired-immunoglobulin like receptor-B (PirB) showed an unaltered or impaired… CONTINUE READING