Altered expression of host-encoded complement regulators on human cytomegalovirus-infected cells.

@article{Spiller1996AlteredEO,
  title={Altered expression of host-encoded complement regulators on human cytomegalovirus-infected cells.},
  author={Owen B Spiller and Bryan Morgan and Frank Tufaro and Dana V. Devine},
  journal={European journal of immunology},
  year={1996},
  volume={26 7},
  pages={1532-8}
}
Human cytomegalovirus (HCMV)-infected cells persist in the presence of anti-HCMV antibody, suggesting that HCMV has evolved mechanisms to evade host immune defenses. Insofar as no virus-encoded complement inhibitors have been identified for HCMV, we hypothesized that HCMV infection may alter the expression of host-encoded cell surface complement inhibitors. Herein, we report that cell surface expression of two complement regulator proteins, CD55 and CD46, which are members of the regulators of… CONTINUE READING

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