Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat.

@article{Dasarathy2007AlteredEO,
  title={Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat.},
  author={Srinivasan Dasarathy and Sean M Muc and Kola Hisamuddin and John M Edmison and Milan Dodig and Arthur Joseph McCullough and Satish C. Kalhan},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={292 4},
  pages={G1105-13}
}
We examined the temporal relationship between portacaval anastomosis (PCA), weight gain, changes in skeletal muscle mass and molecular markers of protein synthesis, protein breakdown, and satellite cell proliferation and differentiation. Male Sprague-Dawley rats with end to side PCA (n=24) were compared with sham-operated pair-fed rats (n=24). Whole body weight, lean body mass, and forelimb grip strength were determined at weekly intervals. The skeletal muscle expression of the ubiquitin… CONTINUE READING

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