Altered expression of genes for Kir ion channels in dilated cardiomyopathy.

  title={Altered expression of genes for Kir ion channels in dilated cardiomyopathy.},
  author={Vikt{\'o}ria Szuts and Dalma M{\'e}nesi and Zolt{\'a}n Varga-Orvos and {\'A}gnes Zvara and Nazanin Houshmand and Mikl{\'o}s Bitay and G{\'a}bor Bog{\'a}ts and L{\'a}szl{\'o} Vir{\'a}g and Istv{\'a}n Baczk{\'o} and Bal{\'a}zs Szalontai and Amir Geramipoor and Diego Cotella and Erich Wettwer and Ursula Ravens and Ferenc De{\'a}k and L{\'a}szl{\'o} G. Pusk{\'a}s and Julius Gy Papp and I. S. Kiss and Andr{\'a}s Varr{\'o} and Norbert Jost},
  journal={Canadian journal of physiology and pharmacology},
  volume={91 8},
Dilated cardiomyopathy (DCM) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration. The Kir2.x K⁺ channels (encoded by KCNJ genes) regulate the inward rectifier current (IK1) contributing to the final repolarization in cardiac muscle. Here, we describe the transitions in the gene expression profiles of 4 KCNJ genes from healthy or dilated cardiomyopathic human hearts. In the healthy adult… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 extracted citations

CaMKII regulation of cardiac K channels

View 3 Excerpts
Highly Influenced

Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171

Reviews of Physiology, Biochemistry and Pharmacology • 2016

Similar Papers

Loading similar papers…