Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice.

@article{Nemoto2000AlteredEO,
  title={Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice.},
  author={Yuji Nemoto and Katsumi Toda and Mafasumi Ono and Kiyomi Fujikawa-Adachi and Toshiji Saibara and Shinsuke Onishi and Hideaki Enzan and Teruhiko Okada and Yutaka Shizuta},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={105 12},
  pages={1819-25}
}
Hepatic steatosis is a frequent complication in nonobese patients with breast cancer treated with tamoxifen, a potent antagonist of estrogen. In addition, hepatic steatosis became evident spontaneously in the aromatase-deficient (ArKO) mouse, which lacks intrinsic estrogen production. These clinical and laboratory observations suggest that estrogen helps to maintain constitutive lipid metabolism. To clarify this hypothesis, we characterized the expression and activity in ArKO mouse liver of… CONTINUE READING

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