Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels.

@article{dny1990AlteredEO,
  title={Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels.},
  author={R{\'o}za {\'A}d{\'a}ny and Robert Heimer and Bruce Caterson and Jessica Sorrell and Renato V Iozzo},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 19},
  pages={11389-96}
}
The connective tissue stroma of malignant tumors is a newly formed tissue that supports the growth and progression of neoplastic cells. Proteoglycans are intrinsic components of this complex structure and molecular changes in this class of macromolecules can significantly affect behavioral properties of transformed cells. We report that human colon… CONTINUE READING