Altered expression of cell cycle genes distinguishes aggressive neuroblastoma

@article{Krasnoselsky2005AlteredEO,
  title={Altered expression of cell cycle genes distinguishes aggressive neuroblastoma},
  author={Alexei L. Krasnoselsky and Craig C. Whiteford and Jun S Wei and Sven Bilke and Frank Westermann and Qing-Rong Chen and Javed Arif Khan},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={1533-1541}
}
In this study, gene expression profiling was performed on 103 neuroblastoma (NB) tumors, stages 1–4 with and without MYCN amplification, using cDNA microarrays containing 42 578 elements. Using principal component analysis (PCA) to analyse the relationships among these samples, we confirm that the global patterns of gene expression reflect the phenotype of the tumors. To explore the biological processes that may contribute to increasing aggressive phenotype of the tumors, we utilized a… CONTINUE READING
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