Altered expression of beta 1 integrins in renal carcinoma cell lines exposed to vinblastine.

Abstract

BACKGROUND Cellular expression of P-glycoprotein (P-gp) which mediates a well characterized mechanism of multidrug resistance (MDR) has been reported previously to be associated with an enhanced tumor dissemination. Since adhesion receptors of the beta 1 integrin family play a substantial role in tumor spread, we studied expression of VLA-1 to -6 in a total… (More)

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