Altered expression of alpha3-containing GABAA receptors in the neocortex of patients with focal epilepsy.

@article{Loup2006AlteredEO,
  title={Altered expression of alpha3-containing GABAA receptors in the neocortex of patients with focal epilepsy.},
  author={Fabienne Loup and Fabienne Picard and V{\'e}ronique Marie Andr{\'e} and Pierre Kehrli and Yasuhiro Yonekawa and H. X. Wieser and J. -M Fritschy},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 12},
  pages={
          3277-89
        }
}
Impaired transmission in GABAergic circuits is thought to contribute to the pathogenesis of epilepsy. Although it is well established that major reorganization of GABA(A) receptor subtypes occurs in the hippocampus of patients with medically refractory temporal lobe epilepsy (TLE), it is unclear whether this disorder is also associated with alterations in GABA(A) receptor subtypes in the neocortex. Here we have investigated immunohistochemically the subunit composition and neocortical… CONTINUE READING

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