Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung’s disease

  title={Altered expression of IL36$\gamma$ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung’s disease},
  author={C. Tomuschat and A. O'donnell and D. Coyle and P. Puri},
  journal={Pediatric Surgery International},
PurposeHirschsprung’s disease associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in Hirschsprung’s disease (HSCR). Altered intestinal epithelial barrier function and abnormal microbiota are implicated in the pathogenesis of HAEC. IL-36γ, a member of the IL-1 superfamily, is involved in host defense and contributes to proinflammatory responses and development of inflammatory diseases. The IL36 receptor (IL1RL2) is an important mediator molecule in the… Expand
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