Altered expression of Gi-protein and adenylyl cyclase activity in hearts from one kidney one clip hypertensive rats: effect of captopril.

@article{Ge1999AlteredEO,
  title={Altered expression of Gi-protein and adenylyl cyclase activity in hearts from one kidney one clip hypertensive rats: effect of captopril.},
  author={Chang Ge and Ra{\'u}l Ignacio Ramos Garc{\'i}a and Madhu B Anand-Srivastava},
  journal={Journal of hypertension},
  year={1999},
  volume={17 11},
  pages={1617-26}
}
OBJECTIVE To investigate whether one kidney one clip (1K-1C) hypertensive rats associated with high levels of angiotensin II (Ang II) exhibit enhanced expression and functions of G proteins in the heart and whether the enhanced expression can be attributed to Ang II. METHODS The levels of G protein and G protein mRNA in hearts from 1K-1C hypertensive rats were determined by immunoblotting and Northern blotting techniques using specific antibodies and cDNA probes, respectively, for different… CONTINUE READING

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